Hartnup disease
Metabolic disorder / From Wikipedia, the free encyclopedia
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Hartnup disease (also known as "pellagra-like dermatosis"[1] and "Hartnup disorder"[2]) is an autosomal recessive[3] metabolic disorder affecting the absorption of nonpolar amino acids (particularly tryptophan that can be, in turn, converted into serotonin, melatonin, and niacin). Niacin is a precursor to nicotinamide (both are forms of vitamin B3), a necessary component of NAD+.[4]:ā541ā
Quick Facts Other names, Specialty ...
Hartnup disease | |
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Other names | Aminoaciduria, Hartnup type |
Tryptophan | |
Specialty | Endocrinology |
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The causative gene, SLC6A19, is located on chromosome 5.[5] It is named after the British family, Hartnup, who had this disease.[citation needed]