Halcinonide

For Halog, the capital of the former Indian Princely State, see Dhami State.

Halcinonide is a high potency corticosteroid, in group II (second most potent group) under US classification.^[1] It is used topically (in a 0.05% cream provided as Halog) in the treatment of certain skin conditions. It is available as a generic medication.^[2]

Halcinonide

Clinical data
Trade names	Halog
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a682272
Routes of administration	Topical
ATC code	D07AD02 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers
IUPAC name (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-6b-(chloroacetyl)-4b-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
CAS Number	3093-35-4 Y
PubChem CID	443943
DrugBank	DB06786 N
ChemSpider	391997 N
UNII	SI86V6QNEG
ChEMBL	ChEMBL1200845 N
CompTox Dashboard (EPA)	DTXSID6045375
ECHA InfoCard	100.019.490
Chemical and physical data
Formula	C24H32ClFO5
Molar mass	454.96 g·mol−1
3D model (JSmol)	Interactive image
SMILES ClCC(=O)[C@]45OC(O[C@@H]5C[C@@H]2[C@@]4(C[C@H](O)[C@]3(F)[C@@]1(/C(=C\C(=O)CC1)CC[C@@H]23)C)C)(C)C
InChI InChI=1S/C24H32ClFO5/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,26)17(28)11-22(16,4)24(19,31-20)18(29)12-25/h9,15-17,19,28H,5-8,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1 N Key:MUQNGPZZQDCDFT-JNQJZLCISA-N N
NY (what is this?)  (verify)

References

1. Pujos E, Flament-Waton MM, Paisse O, Grenier-Loustalot MF (January 2005). "Comparison of the analysis of corticosteroids using different techniques". Anal Bioanal Chem. 381 (1): 244–54. doi:10.1007/s00216-004-2890-9. PMID 15700162. S2CID 19561444.
2. "First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). 8 July 2024. Retrieved 9 July 2024.