H2AFV

Histone H2A.V is a protein that in humans is encoded by the H2AFV gene.^[5]

H2AZ2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WAA
Identifiers
Aliases	H2AZ2, H2A.Z-2, H2AV, H2A histone family member V, H2A.Z variant histone 2, H2AFV
External IDs	MGI: 1924855; HomoloGene: 83271; GeneCards: H2AZ2; OMA:H2AZ2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,826,791 bp[1] End 44,848,087 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 6,377,229 bp[2] End 6,394,443 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence optic nerve rectum mucosa of transverse colon right ventricle epithelium of colon endothelial cell left ventricle Achilles tendon Top expressed in Ileal epithelium medial ganglionic eminence ventricular zone maxillary prominence mandibular prominence endocardial cushion abdominal wall somite migratory enteric neural crest cell thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein heterodimerization activity molecular function Cellular component nucleosome extracellular exosome nucleus chromosome Biological process chromatin organization biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 94239 77605 Ensembl ENSG00000105968 ENSMUSG00000041126 UniProt Q71UI9 Q3THW5 RefSeq (mRNA) NM_201517 NM_012412 NM_138635 NM_201436 NM_201516 NM_029938 NM_001347064 RefSeq (protein) NP_036544 NP_619541 NP_958844 NP_958924 NP_958925 NP_001333993 NP_084214 Location (UCSC) Chr 7: 44.83 – 44.85 Mb Chr 11: 6.38 – 6.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. Several transcripts have been identified for this gene.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000105968 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041126 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: H2AFV H2A histone family, member V".

Further reading

• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–295. doi:10.1006/viro.2000.0593. PMID 11080476.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–326. doi:10.1006/viro.2001.1129. PMID 11689053.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–164. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–6561. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Boyne MT, Pesavento JJ, Mizzen CA, Kelleher NL (2006). "Precise characterization of human histones in the H2A gene family by top down mass spectrometry". J. Proteome Res. 5 (2): 248–253. doi:10.1021/pr050269n. PMID 16457589.
• Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–618. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Histone H2A.V