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GrpE
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GrpE (Gro-P like protein E) is a bacterial nucleotide exchange factor that is important for regulation of protein folding machinery, as well as the heat shock response.[1] It is a heat-inducible protein and during stress it prevents unfolded proteins from accumulating in the cytoplasm.[2][3] Accumulation of unfolded proteins in the cytoplasm can lead to cell death.[4]
Quick Facts Identifiers, Symbol ...
GrpE Protein | |||||||||
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![]() Crystal structure of GrpE homodimer interacting with ATPase binding site of DnaK, resolved at 2.8 angstrom. | |||||||||
Identifiers | |||||||||
Symbol | GrpE | ||||||||
Pfam | PF01025 | ||||||||
InterPro | IPR000740 | ||||||||
PROSITE | PS01071 | ||||||||
SCOP2 | 1dkg / SCOPe / SUPFAM | ||||||||
CDD | cd00446 | ||||||||
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