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Glomerular hyperfiltration
Medical condition / From Wikipedia, the free encyclopedia
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Glomerular hyperfiltration is a situation where the filtration elements in the kidneys called glomeruli produce excessive amounts of pro-urine. It can be part of a number of medical conditions particularly diabetic nephropathy (kidney damage associated with diabetes).[1]
There is no universally accepted definition of glomerular hyperfiltration, and little research has been done on the pathophysiological mechanisms, which are likely to change depending on the underlying ailment.[2]
Glomerular hyperfiltration can result from efferent arteriolar vasoconstriction due to activation of the renin-angiotensin-aldosterone system, which causes glomerular hypertension, or afferent arteriolar vasodilation, as observed in diabetic patients or following a high-protein meal.[2]