GPR12

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.^[5][6][7]

GPR12
Identifiers
Aliases	GPR12, GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12
External IDs	OMIM: 600752; MGI: 101909; HomoloGene: 3868; GeneCards: GPR12; OMA:GPR12 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.13 Start 26,755,200 bp[1] End 26,760,786 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G3 Start 146,519,208 bp[2] End 146,522,049 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence cerebellar hemisphere right hemisphere of cerebellum nucleus accumbens caudate nucleus prefrontal cortex putamen Brodmann area 9 cingulate gyrus anterior cingulate cortex Top expressed in perirhinal cortex entorhinal cortex CA3 field primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell hippocampus proper Region I of hippocampus proper dorsal striatum nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity phosphatidylcholine binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway cellular calcium ion homeostasis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2835 14738 Ensembl ENSG00000132975 ENSMUSG00000041468 UniProt P47775 P35412 RefSeq (mRNA) NM_005288 NM_001010941 NM_008151 NM_001359055 NM_001359056 NM_001359057 NM_001359058 RefSeq (protein) NP_005279 NP_001010941 NP_032177 NP_001345984 NP_001345985 NP_001345986 NP_001345987 Location (UCSC) Chr 13: 26.76 – 26.76 Mb Chr 5: 146.52 – 146.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.^[8]

Ligands

Inverse agonists

• Cannabidiol^[9]

Evolution

Paralogues

Source:^[10]

• GPR6
• GPR3
• S1PR5
• CNR1
• CNR2
• MC4R
• S1PR1
• MC3R
• MC2R
• S1PR2
• MC1R
• S1PR3
• LPAR2
• MC5R
• LPAR1
• S1PR4
• LPAR3
• GPR119

References

1. GRCh38: Ensembl release 89: ENSG00000132975 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041468 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (December 1993). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Letters. 336 (2): 317–22. doi:10.1016/0014-5793(93)80828-I. PMID 8262253. S2CID 31345248.
6. Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.
7. "Entrez Gene: GPR12 G protein-coupled receptor 12".
8. Bjursell M, Gerdin AK, Jönsson M, Surve VV, Svensson L, Huang XF, et al. (September 2006). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–66. doi:10.1016/j.bbrc.2006.07.090. PMID 16887097.
9. Brown KJ, Laun AS, Song ZH (November 2017). "Cannabidiol, a novel inverse agonist for GPR12". Biochemical and Biophysical Research Communications. 493 (1): 451–454. doi:10.1016/j.bbrc.2017.09.001. PMC 5849771. PMID 28888984.
10. "GeneCards®: The Human Gene Database".

Further reading

• Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cellular Physiology and Biochemistry. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592. S2CID 45156405.