![cover image](https://wikiwandv2-19431.kxcdn.com/_next/image?url=https://upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/640px-Ideogram_human_chromosome_7.svg.png&w=640&q=50)
GPNMB
Protein-coding gene in humans / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about GPNMB?
Summarize this article for a 10 year old
Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene.[5] Two transcript variants encoding 560 and 572 amino acid isoforms have been characterized for this gene in humans.[6] The mouse and rat orthologues of GPNMB are known as DC-HIL and Osteoactivin (OA), respectively.[6]
GPNMB is a type I transmembrane glycoprotein which shows homology to the pmel17 precursor, a melanocyte-specific protein.
GPNMB has been reported to be expressed in various cell types, including: melanocytes, osteoclasts, osteoblasts, dendritic cells, and it is overexpressed in various cancer types. In melanocytic cells and osteoclasts the GPNMB gene is transcriptionally regulated by microphthalmia-associated transcription factor.[7][8]