GNG7

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 is a protein that in humans is encoded by the GNG7 gene.^[5][6]

GNG7
Identifiers
Aliases	GNG7, G protein subunit gamma 7, HG3B
External IDs	OMIM: 604430; MGI: 95787; HomoloGene: 31293; GeneCards: GNG7; OMA:GNG7 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,511,219 bp[1] End 2,702,694 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 80,784,458 bp[2] End 80,850,779 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens caudate nucleus putamen inferior ganglion of vagus nerve external globus pallidus C1 segment ventral tegmental area subthalamic nucleus superior vestibular nucleus Amygdala Top expressed in olfactory tubercle nucleus accumbens globus pallidus superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex subiculum hippocampus proper Temporal Lobe Amygdala More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity GTPase activity G-protein beta-subunit binding Cellular component heterotrimeric G-protein complex plasma membrane extracellular exosome membrane G-protein beta/gamma-subunit complex Biological process G protein-coupled receptor signaling pathway cellular response to glucagon stimulus regulation of G protein-coupled receptor signaling pathway signal transduction behavioral fear response receptor guanylyl cyclase signaling pathway locomotory behavior regulation of adenylate cyclase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2788 14708 Ensembl ENSG00000176533 ENSMUSG00000048240 UniProt O60262 Q61016 RefSeq (mRNA) NM_052847 NM_001038655 NM_010319 RefSeq (protein) NP_443079 NP_001033744 NP_034449 NP_001393192 NP_001393193 Location (UCSC) Chr 19: 2.51 – 2.7 Mb Chr 10: 80.78 – 80.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GNG7 has been shown to interact with GNB5.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000176533 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048240 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shibata K, Mori M, Tanaka S, Kitano S, Akiyoshi T (Jun 1998). "Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer". Biochem. Biophys. Res. Commun. 246 (1): 205–9. doi:10.1006/bbrc.1998.8581. PMID 9600093.
6. "Entrez Gene: GNG7 guanine nucleotide binding protein (G protein), gamma 7".
7. Yan K, Kalyanaraman V, Gautam N (Mar 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.

Further reading

• Ueda N, Iñiguez-Lluhi JA, Lee E, Smrcka AV, Robishaw JD, Gilman AG (1994). "G protein beta gamma subunits. Simplified purification and properties of novel isoforms". J. Biol. Chem. 269 (6): 4388–95. doi:10.1016/S0021-9258(17)41792-3. PMID 8308009.
• Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.