GNG13

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 is a protein that in humans is encoded by the GNG13 gene.^[5][6]

GNG13
Identifiers
Aliases	GNG13, G(gamma)13, h2-35, G protein subunit gamma 13, HG3J
External IDs	OMIM: 607298; MGI: 1925616; HomoloGene: 81890; GeneCards: GNG13; OMA:GNG13 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 798,041 bp[1] End 800,734 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 25,936,145 bp[2] End 25,938,380 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum lateral nuclear group of thalamus right frontal lobe gonad anterior cingulate cortex Brodmann area 9 mucosa of transverse colon prefrontal cortex primary visual cortex Amygdala Top expressed in olfactory epithelium lobe of cerebellum neural layer of retina cerebellar vermis deep cerebellar nuclei visual cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell Temporal Lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein beta-subunit binding signal transducer activity GTPase activity Cellular component plasma membrane dendrite membrane heterotrimeric G-protein complex Biological process phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway sensory perception of taste signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51764 64337 Ensembl ENSG00000127588 ENSMUSG00000025739 UniProt Q9P2W3 Q9JMF3 RefSeq (mRNA) NM_016541 NM_022422 NM_001357782 RefSeq (protein) NP_057625 NP_071867 NP_001344711 Location (UCSC) Chr 16: 0.8 – 0.8 Mb Chr 17: 25.94 – 25.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GNG13 has been shown to interact with GNB5.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000127588 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025739 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Huang L, Shanker YG, Dubauskaite J, Zheng JZ, Yan W, Rosenzweig S, Spielman AI, Max M, Margolskee RF (Jan 2000). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium". Nat Neurosci. 2 (12): 1055–62. doi:10.1038/15981. PMID 10570481. S2CID 24494794.
6. "Entrez Gene: GNG13 guanine nucleotide binding protein (G protein), gamma 13".
7. Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP (Dec 2001). "G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)". J. Biol. Chem. 276 (52): 49267–74. doi:10.1074/jbc.M106565200. PMID 11675383.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP (2002). "G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)". J. Biol. Chem. 276 (52): 49267–74. doi:10.1074/jbc.M106565200. PMID 11675383.
• Huang L, Max M, Margolskee RF, Su H, Masland RH, Euler T (2003). "G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells". J. Comp. Neurol. 455 (1): 1–10. doi:10.1002/cne.10396. PMID 12454992. S2CID 22270368.
• Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
• Kato C, Mizutani T, Tamaki H, Kumagai H, Kamiya T, Hirobe A, Fujisawa Y, Kato H, Iwasaki Y (2004). "Characterization of heterotrimeric G protein complexes in rice plasma membrane". Plant J. 38 (2): 320–31. doi:10.1111/j.1365-313X.2004.02046.x. PMID 15078334.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Li Z, Benard O, Margolskee RF (2006). "Ggamma13 interacts with PDZ domain-containing proteins". J. Biol. Chem. 281 (16): 11066–73. doi:10.1074/jbc.M600113200. PMID 16473877.