GNG12

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 is a protein that in humans is encoded by the GNG12 gene.^[5][6]

GNG12
Identifiers
Aliases	GNG12, G protein subunit gamma 12, HG3A
External IDs	OMIM: 615405; MGI: 1336171; HomoloGene: 32427; GeneCards: GNG12; OMA:GNG12 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 67,701,475 bp[1] End 67,833,467 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C1|6 30.68 cM Start 66,873,381 bp[2] End 66,998,334 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa skin of thigh nipple secondary oocyte duodenum skin of hip human penis saphenous vein synovial joint vulva Top expressed in gastrula Ileal epithelium right kidney yolk sac islet of Langerhans uterus jejunum cervix zygote ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphate ion binding PDZ domain binding protein binding signal transducer activity GTPase activity G-protein beta-subunit binding Cellular component plasma membrane extracellular exosome membrane actin filament heterotrimeric G-protein complex G-protein beta/gamma-subunit complex Biological process cerebral cortex development G protein-coupled receptor signaling pathway cellular response to glucagon stimulus response to lipopolysaccharide signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55970 14701 Ensembl ENSG00000172380 ENSMUSG00000036402 UniProt Q9UBI6 Q9DAS9 RefSeq (mRNA) NM_018841 NM_001177556 NM_001177557 NM_001177558 NM_001177559 NM_001177560 NM_025278 RefSeq (protein) NP_061329 NP_001171027 NP_001171028 NP_001171029 NP_001171030 NP_001171031 NP_079554 Location (UCSC) Chr 1: 67.7 – 67.83 Mb Chr 6: 66.87 – 67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000172380 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036402 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hurowitz EH, Melnyk JM, Chen YJ, Kouros-Mehr H, Simon MI, Shizuya H (Sep 2000). "Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes". DNA Res. 7 (2): 111–20. doi:10.1093/dnares/7.2.111. PMID 10819326.
6. "Entrez Gene: GNG12 guanine nucleotide binding protein (G protein), gamma 12".

Further reading

• Morishita R, Nakayama H, Isobe T, et al. (1996). "Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C." J. Biol. Chem. 270 (49): 29469–75. doi:10.1074/jbc.270.49.29469. PMID 7493986.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Morishita R, Saga S, Kawamura N, et al. (1997). "Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain". J. Neurochem. 68 (2): 820–7. doi:10.1046/j.1471-4159.1997.68020820.x. PMID 9003074.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Asano T, Morishita R, Ueda H, Kato K (1999). "Selective association of G protein beta(4) with gamma(5) and gamma(12) subunits in bovine tissues". J. Biol. Chem. 274 (30): 21425–9. doi:10.1074/jbc.274.30.21425. PMID 10409705.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Cook LA, Schey KL, Cleator JH, et al. (2002). "Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms". Protein Sci. 10 (12): 2548–55. doi:10.1110/ps.ps.26401. PMC 2374038. PMID 11714923.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Kato C, Mizutani T, Tamaki H, et al. (2004). "Characterization of heterotrimeric G protein complexes in rice plasma membrane". Plant J. 38 (2): 320–31. doi:10.1111/j.1365-313X.2004.02046.x. PMID 15078334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.