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Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene.[5] Alternatively spliced transcript variants encoding different isoforms exist.[6]
GNB5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | GNB5, guanine nucleotide binding protein (G protein), beta 5, GB5, G protein subunit beta 5, LADCI, IDDCA, gbeta5, HG2E | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 604447; MGI: 101848; HomoloGene: 40714; GeneCards: GNB5; OMA:GNB5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.[6]
GNB5 has been shown to differentially control RGS protein stability and membrane anchor binding, and therefore is involved in the control of complex neuronal G protein signaling pathways.[7]
GNB5 has been shown to interact with:
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