Furanolactone

A furanolactone is a heterocyclic chemical compound that contains both lactone and furan rings in its chemical structure.

The chemical structure of salvinorin A

Examples include:

• The salvinorins,^[1] including the hallucinogenic compound salvinorin A
• Columbin, a bitter diterpenoid from Calumbae Radix^[2][3]
• Limonoids such as limonin, nomilin, and nomilinic acid
• Tinosporide, a diterpenoid originally isolated from Tinospora cordifolia^[4]

References

1. Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Dersch CM, Rothman RB, Prisinzano TE (2006). "Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring". Bioorg Med Chem Lett. 16 (12): 3170–4. doi:10.1016/j.bmcl.2006.03.062.
2. Kohno H, Maeda M, Tanino M, Tsukio Y, Ueda N, Wada K, Sugie S, Mori H, Tanaka T (2002). "A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis". Cancer Lett. 183 (2): 131–139. doi:10.1016/s0304-3835(02)00159-3.
3. Swaminathan K, Sinha UC, Ramakumar S, Bhatt RK, Sabata BK (1989). "Structure of columbin, a diterpenoid furanolactone from Tinospora cordifolia Miers" (PDF). Acta Crystallogr C. 45 (Pt 2): 300–303. doi:10.1107/s0108270188010583.
4. Swaminathan, K.; Sinha, U. C.; Bhatt, R. K.; Sabata, B. K.; Tavale, S. S. (1989). "Structure of tinosporide, a diterpenoid furanolactone from Tinospora cordifolia Miers". Acta Crystallographica Section C. 45 (1): 134–136. Bibcode:1989AcCrC..45..134S. doi:10.1107/s0108270188009953. PMID 2610955.