Functio laesa

Functio laesa is a term used in medicine to refer to a loss of function^[1][2] or a disturbance of function.^[3]

It was identified as the fifth sign of acute inflammation by Galen, who added it to the four signs identified by Celsus (tumor, rubor, calor, and dolor).^[4]

The attribution to Galen is disputed,^[3] and has variously been attributed to Thomas Sydenham^[5] and Rudolf Virchow.^[6]

References

1. "Dorlands Medical Dictionary:cardinal signs".
2. "Definition: functio laesa from Online Medical Dictionary".
3. Rather LJ (March 1971). "Disturbance of function (functio laesa): The legendary fifth cardinal sign of inflammation, added by Galen to the four cardinal signs of Celsus". Bull N Y Acad Med. 47 (3): 303–22. PMC 1749862. PMID 5276838.
4. Porth, Carol (2007). Essentials of pahtophysiology: concepts of altered health states. Hagerstown, MD: Lippincott Williams & Wilkins. p. 270. ISBN 978-0-7817-7087-3.
5. Dormandy, Thomas (2006). The worst of evils: man's fight against pain. New Haven, Conn: Yale University Press. pp. 22. ISBN 0-300-11322-6.
6. David Lowell Strayer; Raphael Rubin (2007). Rubin's Pathology: Clinicopathologic Foundations of Medicine 5th Edition. Hagerstown, MD: Lippincott Williams & Wilkins. p. 37. ISBN 978-0-7817-9516-6.