Frizzled-9

Frizzled-9 (Fz-9) is a protein that in humans is encoded by the FZD9 gene.^[5][6][7] Fz-9 has also been designated as CD349 (cluster of differentiation 349).

FZD9
Identifiers
Aliases	FZD9, CD349, FZD3, frizzled class receptor 9
External IDs	OMIM: 601766; MGI: 1313278; HomoloGene: 2619; GeneCards: FZD9; OMA:FZD9 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.23 Start 73,433,778 bp[1] End 73,436,120 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 75.08 cM Start 135,277,792 bp[2] End 135,280,084 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue muscle of thigh gastrocnemius muscle amygdala cingulate gyrus anterior cingulate cortex prefrontal cortex C1 segment hypothalamus right frontal lobe Top expressed in rib myotome soleus muscle lumbar subsegment of spinal cord lumbar spine ventricular zone stria vascularis plantaris muscle larynx extensor digitorum longus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity signal transducer activity Wnt-protein binding protein heterodimerization activity transmembrane signaling receptor activity G protein-coupled receptor activity Wnt-activated receptor activity Cellular component cytoplasm membrane plasma membrane cell surface perinuclear region of cytoplasm filopodium membrane endoplasmic reticulum membrane Golgi apparatus mitochondrial membranes integral component of membrane postsynapse glutamatergic synapse Biological process G protein-coupled receptor signaling pathway Wnt signaling pathway nervous system development multicellular organism development cell surface receptor signaling pathway learning or memory neuroblast proliferation B cell differentiation signal transduction ossification release of cytochrome c from mitochondria positive regulation of bone mineralization positive regulation of apoptotic process negative regulation of neuron apoptotic process regulation of cytosolic calcium ion concentration negative regulation of mitochondrial depolarization negative regulation of necroptotic process positive regulation of canonical Wnt signaling pathway negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of skeletal muscle acetylcholine-gated channel clustering negative regulation of skeletal muscle acetylcholine-gated channel clustering bone regeneration positive regulation of neural precursor cell proliferation non-canonical Wnt signaling pathway canonical Wnt signaling pathway postsynapse organization regulation of postsynaptic cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8326 14371 Ensembl ENSG00000188763 ENSMUSG00000049551 UniProt O00144 Q9R216 RefSeq (mRNA) NM_003508 NM_010246 RefSeq (protein) NP_003499 NP_034376 Location (UCSC) Chr 7: 73.43 – 73.44 Mb Chr 5: 135.28 – 135.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000188763 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049551 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U (Mar 1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Human Molecular Genetics. 6 (3): 465–72. doi:10.1093/hmg/6.3.465. PMID 9147651.
6. Wang YK, Spörle R, Paperna T, Schughart K, Francke U (Apr 1999). "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome". Genomics. 57 (2): 235–48. doi:10.1006/geno.1999.5773. PMID 10198163.
7. "Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)".

Further reading

• Datta DV (May 1977). "Viral hepatitis (Chandigarh study)". The Journal of the Association of Physicians of India. 25 (5): 325–30. PMID 914765.
• Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (Jun 1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proceedings of the National Academy of Sciences of the United States of America. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
• Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (Aug 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
• Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ (Oct 2002). "Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling". The Journal of Biological Chemistry. 277 (40): 37479–86. doi:10.1074/jbc.M205658200. PMID 12138115.
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.
• Winn RA, Marek L, Han SY, Rodriguez K, Rodriguez N, Hammond M, Van Scoyk M, Acosta H, Mirus J, Barry N, Bren-Mattison Y, Van Raay TJ, Nemenoff RA, Heasley LE (May 2005). "Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation". The Journal of Biological Chemistry. 280 (20): 19625–34. doi:10.1074/jbc.M409392200. PMID 15705594.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Winn RA, Van Scoyk M, Hammond M, Rodriguez K, Crossno JT, Heasley LE, Nemenoff RA (Sep 2006). "Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry. 281 (37): 26943–50. doi:10.1074/jbc.M604145200. PMID 16835228.

External links

• "Frizzled Receptors: FZD₉". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-03-19. Retrieved 2008-12-04.
• FZD9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.