Fluvastatin
Chemical compound / From Wikipedia, the free encyclopedia
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Fluvastatin is a member of the statin drug class, used to treat hypercholesterolemia and to prevent cardiovascular disease.
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Lescol, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a694010 |
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Routes of administration | By mouth (capsules, tablets) |
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Bioavailability | 24–30%[1][2] |
Protein binding | >98%[2] |
Metabolism | Hepatic: CYP2C9 (75%), CYP3A4 (20%), CYP2C8 (5%)[2][3] |
Elimination half-life | 1–3 hours (capsule), 9 hours (XR formulations)[2][3] |
Excretion | Faeces (95%), urine (5%)[2] |
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ECHA InfoCard | 100.224.327 |
Chemical and physical data | |
Formula | C24H26FNO4 |
Molar mass | 411.473 g·mol−1 |
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It was patented in 1982 and approved for medical use in 1994.[4] It is on the World Health Organization's List of Essential Medicines.[5]