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Progestin medication From Wikipedia, the free encyclopedia
Flugestone acetate (FGA), sold under the brand name Cronolone among others, is a progestin medication which is used in veterinary medicine.[1][2][3][4][5][6]
Clinical data | |
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Trade names | Cronolone, others |
Other names | Flurogestone acetate; Fluorogestone acetate; FGA; NSC-65411; SC-9880; 17α-Acetoxy-9α-fluoro-11β-hydroxyprogesterone |
Routes of administration | Intravaginal |
Drug class | Progestogen; Progestin; Progestogen ester |
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CAS Number | |
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ChemSpider | |
UNII | |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.017.979 |
Chemical and physical data | |
Formula | C23H31FO5 |
Molar mass | 406.494 g·mol−1 |
3D model (JSmol) | |
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FGA is used as an intravaginal sponge preparation to synchronize estrus in ewes and goats.[2][4][5][6]
FGA, also known as 17α-acetoxy-9α-fluoro-11β-hydroxyprogesterone or as 17α-acetoxy-9α-fluoro-11β-hydroxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone.[1][3] It is the C17α acetate ester of flugestone.[1][3][2]
FGA was developed and marketed by G.D. Searle & Company in the 1960s.[7][8]
Flugestone acetate is the generic name of the drug and its INN and BANM , while flurogestone acetate is its USAN .[1][3][2][9] Flugestone is the BAN and DCIT of the unesterified free alcohol form.[1][3][2][9] FGA is also known by its developmental code names NSC-65411 and SC-9880.[1][3][2][9]
FGA is or has been marketed under the brand names Chronogest, Chrono-Gest, Crono-Gest, Cronolone, Gyncro-Mate, Ova-Gest, Ovakron, Synchro-Mate, Syncro Part, and Syncropart.[1][3][2][9]
FGA is marketed for veterinary use in Australia, France, Ireland, Israel, Italy, the Netherlands, South Africa, and the United Kingdom.[3][9]
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