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Filgrastim
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Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low neutrophil count.[15] Low neutrophil counts may occur with HIV/AIDS, following chemotherapy or radiation poisoning, or be of an unknown cause.[15] It may also be used to increase white blood cells for gathering during leukapheresis.[15] It is given either by injection into a vein or under the skin.[15] Filgrastim is a leukocyte growth factor.[14]
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Trade names | Neupogen, others |
Other names | XM02 |
Biosimilars | filgrastim-aafi,[1] filgrastim-ayow,[2] filgrastim-sndz, filgrastim-txid[3] Accofil, Biograstim, Fraven Grastofil, Nivestim,[4] Nivestym,[5] Nypozi,[3][6] Ratiograstim, Releuko,[2] Tevagrastim, Zarxio,[7] Zarzio[8] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a692033 |
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Routes of administration | Intraveneous, subcutaneous |
Drug class | Hematopoietic agents, colony-stimulating factors |
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ECHA InfoCard | 100.167.401 ![]() |
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Formula | C845H1343N223O243S9 |
Molar mass | 18802.90 g·mol−1 |
Common side effects include fever, cough, chest pain, joint pain, vomiting, and hair loss.[15] Severe side effects include splenic rupture and allergic reactions.[15] It is unclear if use in pregnancy is safe for the baby.[15] Filgrastim is a recombinant form of the naturally occurring granulocyte colony-stimulating factor (G-CSF).[15] It works by stimulating the body to increase neutrophil production.[15]
Filgrastim was approved for medical use in the United States in 1991.[15] It is on the World Health Organization's List of Essential Medicines.[16][17] Filgrastim biosimilar medications are available.[15]