Fezolinetant
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Fezolinetant, sold under the brand name Veozah among others, is a medication used for the treatment of hot flashes (vasomotor symptoms) due to menopause.[2][8] It is a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist which is under development by for the treatment of sex hormone-related disorders.[medical citation needed] It is taken by mouth.[2] It is developed by Astellas Pharma which acquired it from Ogeda (formerly Euroscreen) in April 2017.[9][10][11]
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Trade names | Veozah, Veoza |
Other names | ESN-364 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a623051 |
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Routes of administration | By mouth |
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Protein binding | 51%[5][unreliable medical source?] |
Metabolism | CYP1A2, (CYP2C9, CYP2C19 to lesser extent)[2] |
Metabolites | ES259564[6] |
Elimination half-life | 9.6h[2] |
Excretion | Urine 76.9%, feces 14.7%[7][unreliable medical source?] |
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Formula | C16H15FN6OS |
Molar mass | 358.40 g·mol−1 |
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The most common side effects include abdominal pain, diarrhea, insomnia, back pain, hot flush and elevated hepatic transaminases.[8]
Fezolinetant was approved for medical use in the United States in May 2023,[8] and in the European Union in December 2023.[3][4] Fezolinetant is the first neurokinin 3 (NK3) receptor antagonist approved by the US Food and Drug Administration (FDA) to treat moderate to severe hot flashes from menopause.[8] The FDA considers it to be a first-in-class medication.[12]