Fenoverine

Fenoverine (INN) is an antispasmodic [also known as spasmolytics] drug,^[1] which acts by inhibiting calcium channels^[2] [much in the same way as traditional calcium channel blockers, which are used as antianginal drugs]. In the case of Fenoverine, the relaxation occurs in abdominal / intestinal smooth muscles, while in case of antianginal drugs, the relaxation occurs in coronary vessels. Notably Fenoverine does not act as an antianginal agent.

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You can help expand this article with text translated from the corresponding article in Italian. (May 2014) Click [show] for important translation instructions.

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Quick Facts Clinical data, AHFS/Drugs.com ...

Fenoverine
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	A03AX05 (WHO)
Identifiers
IUPAC name 2-[4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl]-1-(10H-phenothiazin-10-yl)ethanone
CAS Number	37561-27-6
PubChem CID	72098
ChemSpider	65083
UNII	N274ZQ6PZJ
KEGG	D07095^Y
ChEMBL	ChEMBL1512949
CompTox Dashboard (EPA)	DTXSID8046296
ECHA InfoCard	100.048.666
Chemical and physical data
Formula	C₂₆H₁₅N₃O₃S
Molar mass	449.48 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CN(CCN1CC2=CC3=C(C=C2)OCO3)CC(=O)N4C5=CC=CC=C5SC6=CC=CC=C64
InChI InChI=1S/C26H25N3O3S/c30-26(29-20-5-1-3-7-24(20)33-25-8-4-2-6-21(25)29)17-28-13-11-27(12-14-28)16-19-9-10-22-23(15-19)32-18-31-22/h1-10,15H,11-14,16-18H2 Key:UBAJTZKNDCEGKL-UHFFFAOYSA-N
(verify)

Fenoverine is known to cause rhabdomyolysis.^[2]^[3]

[1]
Martínez-Vázquez MA, Vázquez-Elizondo G, González-González JA, Gutiérrez-Udave R, Maldonado-Garza HJ, Bosques-Padilla FJ (2012). "Effect of antispasmodic agents, alone or in combination, in the treatment of Irritable Bowel Syndrome: systematic review and meta-analysis". Revista de Gastroenterologia de Mexico. 77 (2): 82–90. doi:10.1016/j.rgmx.2012.04.002. PMID 22672854.
[2]
Chariot P, Ratiney R, Le Maguet F, Fourestié V, Astier A, Gherardi R (August 1995). "Fenoverine-induced rhabdomyolysis". Hum Exp Toxicol. 14 (8): 654–656. doi:10.1177/096032719501400805. PMID 7576832.
[3]
Cho J, Na J, Bae E, Lee TW, Jang HN, Cho HS, Chang SH, Park DJ (April 2020). "The incidence, risk factors, and clinical outcomes of rhabdomyolysis associated with fenoverine prescription: a retrospective study in South Korea (1999-2014)". BMC Pharmacol Toxicol. 21 (1): 30. doi:10.1186/s40360-020-00408-3. PMC 7183697. PMID 32334639.

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

This article needs additional citations for verification. (May 2021)

You can help expand this article with text translated from the corresponding article in Italian. (May 2014) Click [show] for important translation instructions.

Machine translation, like DeepL or Google Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Wikipedia.
Consider adding a topic to this template: there are already 695 articles in the main category, and specifying|topic= will aid in categorization.
Do not translate text that appears unreliable or low-quality. If possible, verify the text with references provided in the foreign-language article.
You must provide copyright attribution in the edit summary accompanying your translation by providing an interlanguage link to the source of your translation. A model attribution edit summary is Content in this edit is translated from the existing Italian Wikipedia article at [[:it:Fenoverina]]; see its history for attribution.
You may also add the template {{Translated|it|Fenoverina}} to the talk page.
For more guidance, see Wikipedia:Translation.

Quick Facts Clinical data, AHFS/Drugs.com ...

Fenoverine
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	A03AX05 (WHO)
Identifiers
IUPAC name 2-[4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl]-1-(10H-phenothiazin-10-yl)ethanone
CAS Number	37561-27-6
PubChem CID	72098
ChemSpider	65083
UNII	N274ZQ6PZJ
KEGG	D07095^Y
ChEMBL	ChEMBL1512949
CompTox Dashboard (EPA)	DTXSID8046296
ECHA InfoCard	100.048.666
Chemical and physical data
Formula	C₂₆H₁₅N₃O₃S
Molar mass	449.48 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CN(CCN1CC2=CC3=C(C=C2)OCO3)CC(=O)N4C5=CC=CC=C5SC6=CC=CC=C64
InChI InChI=1S/C26H25N3O3S/c30-26(29-20-5-1-3-7-24(20)33-25-8-4-2-6-21(25)29)17-28-13-11-27(12-14-28)16-19-9-10-22-23(15-19)32-18-31-22/h1-10,15H,11-14,16-18H2 Key:UBAJTZKNDCEGKL-UHFFFAOYSA-N
(verify)

Fenoverine is known to cause rhabdomyolysis.^[2]^[3]

[1]
Martínez-Vázquez MA, Vázquez-Elizondo G, González-González JA, Gutiérrez-Udave R, Maldonado-Garza HJ, Bosques-Padilla FJ (2012). "Effect of antispasmodic agents, alone or in combination, in the treatment of Irritable Bowel Syndrome: systematic review and meta-analysis". Revista de Gastroenterologia de Mexico. 77 (2): 82–90. doi:10.1016/j.rgmx.2012.04.002. PMID 22672854.
[2]
Chariot P, Ratiney R, Le Maguet F, Fourestié V, Astier A, Gherardi R (August 1995). "Fenoverine-induced rhabdomyolysis". Hum Exp Toxicol. 14 (8): 654–656. doi:10.1177/096032719501400805. PMID 7576832.
[3]
Cho J, Na J, Bae E, Lee TW, Jang HN, Cho HS, Chang SH, Park DJ (April 2020). "The incidence, risk factors, and clinical outcomes of rhabdomyolysis associated with fenoverine prescription: a retrospective study in South Korea (1999-2014)". BMC Pharmacol Toxicol. 21 (1): 30. doi:10.1186/s40360-020-00408-3. PMC 7183697. PMID 32334639.

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

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Toxicity

References