Familial Mediterranean fever
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Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder.[1]: 149 FMF is an autoinflammatory disease caused by mutations in Mediterranean fever gene, which encodes a 781–amino acid protein called pyrin.[2] While all ethnic groups are susceptible to FMF, it usually occurs in people of Mediterranean origin—including Sephardic Jews, Mizrahi Jews, Ashkenazi Jews,[3][4] Assyrians, Armenians, Azerbaijanis, Druze, Levantines, Kurds, Greeks, Turks and Italians.[5][6][7][8]
Familial Mediterranean fever | |
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Familial Mediterranean fever has an autosomal recessive pattern of inheritance | |
Specialty | Rheumatology, Immunology |
The disorder has been given various names, including familial paroxysmal polyserositis, periodic peritonitis, recurrent polyserositis, benign paroxysmal peritonitis, periodic disease or periodic fever, Reimann periodic disease or Reimann syndrome, Siegal-Cattan-Mamou disease, and Wolff periodic disease.[9][10][11] Note that "periodic fever" can also refer to any of the periodic fever syndromes.