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Famciclovir
Chemical compound / From Wikipedia, the free encyclopedia
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Famciclovir is a guanosine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Novartis).
Quick Facts Clinical data, Pronunciation ...
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Pronunciation | /ˌfæmˈsaɪkloʊˌvɪər/[1] |
Trade names | Famvir |
AHFS/Drugs.com | Monograph |
MedlinePlus | a694038 |
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Routes of administration | By mouth |
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Bioavailability | 75–77% |
Protein binding | 20–25% |
Metabolism | Liver, circulation, intestinal wall (to penciclovir) |
Elimination half-life | 2–2.3 hours |
Excretion | Kidney, faecal |
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ECHA InfoCard | 100.158.713 ![]() |
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Formula | C14H19N5O4 |
Molar mass | 321.337 g·mol−1 |
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Melting point | 103 °C (217 °F) |
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Famciclovir was patented in 1983 and approved for medical use in 1994.[3][4] In 2007, the United States Food and Drug Administration approved the first generic version of famciclovir. Generic tablets are manufactured by TEVA Pharmaceuticals and Mylan Pharmaceuticals.[5][6]