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Etizolam
Benzodiazepine analog drug / From Wikipedia, the free encyclopedia
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Etizolam (marketed under many brand names) is a thienodiazepine derivative[5] which is a benzodiazepine analog.[6] The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring and triazole ring has been fused, making the drug a thienotriazolodiazepine.[7][8]
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Trade names | Etizest, Etilaam, Etizex, Depas, Sedekopan, Pasaden |
Dependence liability | Moderate |
Routes of administration | Oral, sublingual, rectal |
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Bioavailability | 93% |
Metabolism | Hepatic |
Elimination half-life | 3.4 hours[2][3] (main metabolite is 8.2 hours)[4] |
Duration of action | 5-7 hours |
Excretion | Kidney |
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ECHA InfoCard | 100.188.773 ![]() |
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Formula | C17H15ClN4S |
Molar mass | 342.85 g·mol−1 |
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![Thumb image](http://upload.wikimedia.org/wikipedia/commons/thumb/9/91/PureEtizolam.jpg/640px-PureEtizolam.jpg)
![Four blister packs of Etizex brand etizolam tablets](http://upload.wikimedia.org/wikipedia/commons/thumb/4/4f/Etizex_brand_etizolam_tablets.jpg/640px-Etizex_brand_etizolam_tablets.jpg)
Although a thienodiazepine, etizolam is clinically regarded as a benzodiazepine because of its mode of action via the benzodiazepine receptor and directly targeting GABAA allosteric modulator receptors.[5]
It possesses anxiolytic, amnesic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.[9]
It was patented in 1972[10] and approved for medical use[where?] in 1983.[11]
As of April 2021, the export of etizolam has been banned in India.[12]