Estradiol hexahydrobenzoate
Chemical compound / From Wikipedia, the free encyclopedia
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Estradiol hexahydrobenzoate (EHHB), sold under a number of brand names including Benzo-Ginoestril A.P., BenzoGynoestryl Retard, Ginestryl-15-Depot, Menodin, and Tardoginestryl, is an estrogen medication which was previously used for indications such as menopausal hormone therapy and gynecological disorders.[1][2][3][4][5] EHHB is given by injection into muscle at regular intervals, for instance once every few weeks.[3][5][6][7]
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Trade names | Benzo-Ginoestril A.P., BenzoGynoestryl Retard, Ginestryl-15-Depot, Menodin, Tardoginestryl |
Other names | EHHB; Estradiol cyclohexanecarboxylate; ECHC; Oestradiol hexahydrobenzoate; Estradiol 17β-hexahydrobenzoate; Estradiol 17β-cyclohexanecarboxylate; Estradiol hexabenzoate |
Routes of administration | Intramuscular injection |
Drug class | Estrogen; Estrogen ester |
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ECHA InfoCard | 100.035.623 |
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Formula | C25H34O3 |
Molar mass | 382.544 g·mol−1 |
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Side effects of EHHB include breast tenderness, breast enlargement, nausea, headache, and fluid retention.[8] EHHB is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol.[9][10] It is an estrogen ester and a prodrug of estradiol in the body.[10][9] Because of this, it is considered to be a natural and bioidentical form of estrogen.[10]
EHHB was first described in 1956,[11][12] and was introduced for medical use by 1957.[6] It was used in France.[6] The medication should not be confused with estradiol benzoate (EB), which has been marketed under similar brand names including Benzo-Ginestryl, Benzo-Ginoestril, and Benzo-Gynoestryl.[3][6][13]