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Species of virus From Wikipedia, the free encyclopedia
Escherichia virus HK97, often shortened to HK97, is a species of virus that infects Escherichia coli and related bacteria. It is named after Hong Kong (HK), where it was first located. HK97 has a double-stranded DNA genome.
Escherichia virus HK97 | |
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Virus classification ![]() | |
(unranked): | Virus |
Realm: | Duplodnaviria |
Kingdom: | Heunggongvirae |
Phylum: | Uroviricota |
Class: | Caudoviricetes |
Order: | Caudovirales |
Family: | Siphoviridae |
Genus: | Hendrixvirus |
Species: | Escherichia virus HK97 |
The major capsid protein of HK97, called gp5, cross-links upon maturation to form a chain-mail like structure.[1] While DNA is being packaged into the capsid, the capsid expands by nearly 5 nm and changes from spherical to icosahedral in shape.[citation needed]
The HK97 assembly pathway begins with self-assembly of gp5 into pentamers and hexamers. A protease, called gp4, cleaves gp5 at its N-terminus. Attachment of a portal protein, gp3, coupled with conformational changes leads to the formation of a prohead, or procapsid, which is the precursor to the mature capsid.[2] A scaffolding protein is not required for capsid assembly.[3] However, studies on the effects of deleting the delta domain of the major capsid protein, or parts of it, indicate that it is essential for assembly.[4]
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