![cover image](https://wikiwandv2-19431.kxcdn.com/_next/image?url=https://upload.wikimedia.org/wikipedia/commons/thumb/4/4d/EphA5.png/640px-EphA5.png&w=640&q=50)
Ephrin receptor
Protein family / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Ephrin receptor?
Summarize this article for a 10 year old
Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins). Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Eph receptors and their corresponding ephrin ligands are membrane-bound proteins that require direct cell-cell interactions for Eph receptor activation. Eph/ephrin signaling has been implicated in the regulation of a host of processes critical to embryonic development including axon guidance,[1] formation of tissue boundaries,[2] cell migration, and segmentation.[3] Additionally, Eph/ephrin signaling has been identified to play a critical role in the maintenance of several processes during adulthood including long-term potentiation,[4] angiogenesis,[5] and stem cell differentiation and cancer.[6]
Eph receptor ligand binding domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
![]() Structure of the kinase domain of human eph type-A receptor 5 (EphA5) | |||||||||
Identifiers | |||||||||
Symbol | Ephrin_lbd | ||||||||
Pfam | PF01404 | ||||||||
InterPro | IPR016257 | ||||||||
SCOP2 | 1nuk / SCOPe / SUPFAM | ||||||||
CDD | cd10319 | ||||||||
Membranome | 1202 | ||||||||
|