ERM protein family
Protein family / From Wikipedia, the free encyclopedia
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The ERM protein family consists of three closely related proteins, ezrin,[2] radixin[3] and moesin.[4][5] The three paralogs, ezrin, radixin and moesin, are present in vertebrates, whereas other species have only one ERM gene. Therefore, in vertebrates these paralogs likely arose by gene duplication.[6]
Quick Facts Ezrin/radixin/moesin family, Identifiers ...
Ezrin/radixin/moesin family | |||||||||||
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Identifiers | |||||||||||
Symbol | ERM | ||||||||||
Pfam | PF00769 | ||||||||||
InterPro | IPR011259 | ||||||||||
SCOP2 | 1ef1 / SCOPe / SUPFAM | ||||||||||
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ERM proteins are highly conserved throughout evolution. More than 75% identity is observed in the N-terminal and the C-terminal of vertebrates (ezrin, radixin, moesin), Drosophila (dmoesin) and C. elegans (ERM-1) homologs.[7]