Discovery and development of triptans
Development of a class of anti-migraine drugs / From Wikipedia, the free encyclopedia
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Triptans are a family of tryptamine-based drugs used as abortive medication in the treatment of migraines and cluster headaches. They are selective 5-hydroxytryptamine/serotonin1B/1D (5-HT1B/1D) agonists.[1] Migraine is a complex disease which affects about 15% of the population and can be highly disabling.[2] Triptans have advantages over ergotamine and dihydroergotamine, such as selective pharmacology, well established safety record and evidence-based prescribing instructions. Triptans are therefore often preferred treatment in migraine.[1]