Dipentylone

N,N-Dimethylpentylone (also known as Dipentylone or simply Dimethylpentylone) is a substituted cathinone derivative with stimulant effects,^[1] which has been sold as a designer drug,^[2][3] first detected in Sweden in 2014.^[4]

N,N-Dimethylpentylone

Legal status
Legal status	DE: NpSG (Industrial and scientific use only) UK: Class B US: Schedule I
Identifiers
IUPAC name 1-(1,3-benzodioxol-5-yl)-2-(dimethylamino)pentan-1-one
CAS Number	803614-36-0 Y 17763-13-2 (Hydrochloride)
PubChem CID	119057570
ChemSpider	52085278
UNII	V41961I345
CompTox Dashboard (EPA)	DTXSID501342478
Chemical and physical data
Formula	C14H19NO3
Molar mass	249.310 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCC(C(=O)C1=CC2=C(C=C1)OCO2)N(C)C
InChI InChI=1S/C14H19NO3/c1-4-5-11(15(2)3)14(16)10-6-7-12-13(8-10)18-9-17-12/h6-8,11H,4-5,9H2,1-3H3 Key:PQTJKFUXRBKONZ-UHFFFAOYSA-N

Pharmacology

Pentylone is a known metabolite of dimethylpentylone.^{[medical citation needed]}

Society and Culture

Dimethylpentylone was first identified in toxicology samples in the US in late 2021 and has been tracked by the Center for Forensic Science Research and Education (CFSRE) through its NPS Discovery program as an increasingly common drug mismarketed as MDMA where Eutylone was previously commonly mismarketed as MDMA.^[5]

On June 26, 2023, the United States Customs and Border Protection seized 32.2 kilograms of dimethylpentylone, sent from China labeled as "beauty products" mailed to an address in Washington, D.C.^[6][7]

On July 10, 2023, Jacksonville DEA Assistant Special Agent in Charge Mike Dubet gave an interview to WJXT (news4jax) reporting that dimethylpentylone has been found in possession by people attending nightclubs and bars in the Jacksonville, Florida area.^[8]

Legal Status

Dimethylpentylone is not specifically listed in the United States Controlled Substance Act but would be considered Schedule I as a positional isomer of the Schedule I substance N-Ethylpentylone in the United States, defined as "all isomers" within that definition.^[9][10]

See also

• Dibutylone
• Diethylpropion
• Dimethylone
• Ephylone
• Isohexylone
• MDPV
• N-Ethylhexedrone
• N-Ethylhexylone
• Pentylone

References

1. Gatch MB, Shetty RA, Sumien N, Forster MJ (July 2021). "Behavioral effects of four novel synthetic cathinone analogs in rodents". Addiction Biology. 26 (4): e12987. doi:10.1111/adb.12987. PMID 33155384. S2CID 226271372.
2. Celma A, Sancho JV, Salgueiro-González N, Castiglioni S, Zuccato E, Hernández F, Bijlsma L (September 2019). "Simultaneous determination of new psychoactive substances and illicit drugs in sewage: Potential of micro-liquid chromatography tandem mass spectrometry in wastewater-based epidemiology". Journal of Chromatography A. 1602: 300–309. doi:10.1016/j.chroma.2019.05.051. hdl:10234/182680. PMID 31171357. S2CID 174814822.
3. "Police and drug agency issue strong warning after new drug detected in Dunedin". New Zealand Herald. 8 December 2021.
4. "Europol 2014 Annual Report on the implementation of Council Decision" (PDF). European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) – Europol. 2005/387/JHA.
5. "Synthetic Stimulant Market Rapidly Changing as N,N-Dimethylpentylone Replaces Eutylone in Drug Supply Typically Sold as "Ecstasy" or "Molly"". 20 April 2022.
6. "Dulles CBP Officers Seize 70 Pounds of a Dangerous, Newer Cathinone Analogue Destined to D.C. | U.S. Customs and Border Protection". www.cbp.gov. Retrieved 2023-08-10.
7. "70 pounds of psychoactive drugs from China labeled as beauty products seized at US airport: officials". Fox News. 2023-07-06. Retrieved 2023-08-10.
8. Avanier E (2023-07-11). "Newest drug to hit the streets makes its way to Northeast Florida nightclubs, bars". WJXT. Retrieved 2023-08-10.
9. "2020 - Placement of N-Ethylpentylone in Schedule I".
10. "2007 - Definition of 'Positional Isomer' as It Pertains to the Control of Schedule I Controlled Substances".