Desoxycorticosterone acetate

Desoxycorticosterone acetate (also known as DOCA and 11-deoxycorticosterone 21-acetate and sold under the brand names Percorten Acetate and Decosterone, among others) is a mineralocorticoid medication and a mineralocorticoid ester.^[1][2] It is formulated as an oil solution and is administered once daily by intramuscular injection.^[3] The medication is the C21 acetate ester of 11-deoxycorticosterone.^[1][2]

Desoxycorticosterone acetate

Clinical data
Trade names	Percorten Acetate, Decosterone, others
Other names	DOCA; 11-Deoxycorticosterone 21-acetate; 21-Acetoxypregn-4-ene-3,20-dione
Routes of administration	Intramuscular injection
Drug class	Corticosteroid; Mineralocorticoid
Identifiers
IUPAC name [2-[(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
CAS Number	56-47-3
PubChem CID	5952
DrugBank	DB06780
ChemSpider	5737
UNII	6E0A168OB8
KEGG	D03698
ChEBI	CHEBI:34671
ChEMBL	ChEMBL1200542
CompTox Dashboard (EPA)	DTXSID6022894
ECHA InfoCard	100.000.251
Chemical and physical data
Formula	C23H32O4
Molar mass	372.505 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(=O)OCC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C
InChI InChI=1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1 Key:VPGRYOFKCNULNK-ACXQXYJUSA-N

References

1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 665–. ISBN 978-1-4757-2085-3.
2. Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory. Taylor & Francis. pp. 306–307. ISBN 978-3-88763-075-1.
3. Chien YW (1981). "Long-acting parenteral drug formulations". J Parenter Sci Technol. 35 (3): 106–39. PMID 6113276.