Degmacyte
Abnormally shaped mature red blood cell / From Wikipedia, the free encyclopedia
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A degmacyte or bite cell is an abnormally shaped mature red blood cell with one or more semicircular portions removed from the cell margin, known as "bites".[1][2] These "bites" result from the mechanical removal of denatured hemoglobin during splenic filtration as red cells attempt to migrate through endothelial slits from splenic cords into the splenic sinuses.[3] Bite cells are known to be a result from processes of oxidative hemolysis, such as Glucose-6-phosphate dehydrogenase deficiency, in which uncontrolled oxidative stress causes hemoglobin to denature and form Heinz bodies.[4] Bite cells can contain more than one "bite." The "bites" in degmacytes are smaller than the missing red blood cell fragments seen in schistocytes.[citation needed]
Degmacytes usually appear smaller, denser, and more contracted than a normal red blood cell due to the bites.[5] The appearance of the "bites" in red blood cells may vary in number, smoothness, and size.[5] These cells can also exhibit other peripheral effects.[2]