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Dasatinib
Chemical compound / From Wikipedia, the free encyclopedia
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Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL).[3] Specifically it is used to treat cases that are Philadelphia chromosome-positive (Ph+).[3] It is taken by mouth.[3]
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Trade names | Sprycel, Dasanix |
AHFS/Drugs.com | Monograph |
MedlinePlus | a607063 |
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Routes of administration | By mouth (tablets) |
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Protein binding | 96% |
Metabolism | Liver |
Elimination half-life | 1.3 to 5 hours |
Excretion | Fecal (85%), kidney (4%) |
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ECHA InfoCard | 100.228.321 ![]() |
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Formula | C22H26ClN7O2S |
Molar mass | 488.01 g·mol−1 |
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Common adverse effects include low white blood cells, low blood platelets, anemia, swelling, rash, and diarrhea.[3] Severe adverse effects may include bleeding, pulmonary edema, heart failure, and prolonged QT syndrome.[3] Use during pregnancy may result in harm to the baby.[3] It is a tyrosine-kinase inhibitor and works by blocking a number of tyrosine kinases such as Bcr-Abl and the Src kinase family.[3]
Dasatinib was approved for medical use in the United States and in the European Union in 2006.[3][2] It is on the World Health Organization's List of Essential Medicines.[4]