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Darunavir
Antiretroviral medication / From Wikipedia, the free encyclopedia
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Darunavir (DRV), sold under the brand name Prezista among others, is an antiretroviral medication used to treat and prevent HIV/AIDS.[1] It is generally recommended for use with other antiretrovirals.[1][4] It is often used with low doses of ritonavir or cobicistat to increase darunavir levels.[1] It may be used for prevention after a needlestick injury or other potential exposure.[1] It is taken by mouth once to twice a day.[1]
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Clinical data | |
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Trade names | Prezista, others[1] |
Other names | TMC114, DRV, darunavir ethanolate |
AHFS/Drugs.com | Monograph |
MedlinePlus | a607042 |
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Routes of administration | By mouth |
Drug class | HIV protease inhibitor |
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Bioavailability | 37% (without ritonavir), 82% (with ritonavir) |
Protein binding | 95% |
Metabolism | Liver (CYP3A4) |
Elimination half-life | 15 hours (with ritonavir) |
Excretion | Feces (80%), urine (14%) |
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ECHA InfoCard | 100.111.730 ![]() |
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Formula | C27H37N3O7S |
Molar mass | 547.67 g·mol−1 |
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Common side effects include diarrhea, nausea, abdominal pain, headache, rash and vomiting.[1][4] Severe side effects include allergic reactions, liver problems, and skin rashes such as toxic epidermal necrolysis.[1] While poorly studied in pregnancy it appears to be safe for the baby.[2] It is of the protease inhibitor (PI) class and works by blocking HIV protease.[1]
Darunavir was approved by the US Food and Drug Administration (FDA) in June 2006.[6][7] It is on the World Health Organization's List of Essential Medicines.[8] It is available as a generic medication.[9]
It is available in the fixed-dose combination medication darunavir/cobicistat (Prezcobix, Rezolsta),[10][11] and in the fixed-dose combination medication darunavir/cobicistat/emtricitabine/tenofovir alafenamide (Symtuza).[12][13]