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Daptomycin
Antibiotic / From Wikipedia, the free encyclopedia
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Daptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms.[4]
Quick Facts Clinical data, Trade names ...
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Clinical data | |
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Trade names | Cubicin, Cubicin RF, Dapzura RT |
Other names | LY 146032 |
AHFS/Drugs.com | Monograph |
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Routes of administration | Intravenous |
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Bioavailability | n/a |
Protein binding | 90–95% |
Elimination half-life | 7–11 hours (up to 28 hours in renal impairment) |
Excretion | Kidney (78%; primarily as unchanged drug); faeces (5.7%) |
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ECHA InfoCard | 100.116.065 ![]() |
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Formula | C72H101N17O26 |
Molar mass | 1620.693 g·mol−1 |
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Quick Facts Identifiers, Symbol ...
Daptomycin | |
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![]() 1. Daptomycin binds and inserts into the cell membrane. 2. It aggregates in the membrane. 3. It alters the shape of the membrane to form a hole, allowing ions in and out of the cell easily. | |
Identifiers | |
Symbol | N/A |
TCDB | 1.D.15 |
OPM superfamily | 163 |
OPM protein | 1t5n |
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Daptomycin was removed from the World Health Organization's List of Essential Medicines in 2019.[7][8] The World Health Organization classifies daptomycin as critically important for human medicine.[9]