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Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
DNA cross-link repair 1A protein is a protein that in humans is encoded by the DCLRE1A gene.[5][6][7]
DCLRE1A | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | DCLRE1A, PSO2, SNM1, SNM1A, DNA cross-link repair 1A | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 609682; MGI: 1930042; HomoloGene: 8920; GeneCards: DCLRE1A; OMA:DCLRE1A - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000).[supplied by OMIM][7]
The protein DCLRE1A (DNA cross-link repair 1A) is also referred to as SNM1A (sensitive to nitrogen mustard 1A). DCLRE1A is a 5’ to 3’ exonuclease that forms a complex with the Cockayne syndrome B (CSB) protein. In this complex, CSB modulates the exonuclease activity of DCLRE1A and coordinates the efficient assembly of DCLRE1A to sites of DNA damage.[8] In human cells, this complex is recruited to DNA inter-strand cross-links, a form of DNA damage. The complex then participates in the repair of the cross-linked DNA. DCLRE1A protein is thought to be recruited by CSB to facilitate cross-link unhooking following incision 5’ to the cross-link by another complex, the ERCC1/XPF nuclease complex.[8] Failure of the DCLRE1A/CSB complex to carry out its repair function may contribute to the degenerative pathologies and premature aging features of Cockayne syndrome.
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