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Cystathionine gamma-lyase
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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The enzyme cystathionine γ-lyase (EC 4.4.1.1, CTH or CSE; also cystathionase; systematic name L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)) breaks down cystathionine into cysteine, 2-oxobutanoate (α-ketobutyrate), and ammonia:
- L-cystathionine + H2O = L-cysteine + 2-oxobutanoate + NH3 (overall reaction)
- (1a) L-cystathionine = L-cysteine + 2-aminobut-2-enoate
- (1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous)
- (1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous)
Quick Facts Identifiers, EC no. ...
cystathionine γ-lyase | |||||||||
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![]() Cysteine metabolism. Cystathionase catalyzes the lower reaction. | |||||||||
Identifiers | |||||||||
EC no. | 4.4.1.1 | ||||||||
CAS no. | 9012-96-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts cystathionase (cystathionine γ-lyase), Identifiers ...
cystathionase (cystathionine γ-lyase) | |||||||
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Identifiers | |||||||
Symbol | CTH | ||||||
NCBI gene | 1491 | ||||||
HGNC | 2501 | ||||||
OMIM | 607657 | ||||||
RefSeq | NM_001902 | ||||||
UniProt | P32929 | ||||||
Other data | |||||||
EC number | 4.4.1.1 | ||||||
Locus | Chr. 1 p31.1 | ||||||
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Pyridoxal phosphate is a prosthetic group of this enzyme.[1][2][3]
Cystathionine γ-lyase also catalyses the following elimination reactions:
- L-homoserine to form H2O, NH3 and 2-oxobutanoate
- L-cystine, producing thiocysteine, pyruvate and NH3[4]
- L-cysteine producing pyruvate, NH3 and H2S
In some bacteria and mammals, including humans, this enzyme takes part in generating hydrogen sulfide.[2][5] Hydrogen sulfide is one of a few gases that was recently discovered to have a role in cell signaling in the body.[6]