Cyclobenzaprine
Muscle relaxant medication / From Wikipedia, the free encyclopedia
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Cyclobenzaprine, sold under several brand names including, historically, Flexeril, is a muscle relaxer used for muscle spasms from musculoskeletal conditions of sudden onset.[5] It is not useful in cerebral palsy.[5] It is taken by mouth.[5]
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Trade names | Flexeril, Amrix, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682514 |
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Routes of administration | By mouth |
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Bioavailability | 33–55%[1][2] |
Protein binding | 93% |
Metabolism | major: CYP3A4, CYP1A2; minor: CYP2D6, N-demethylation[3] |
Metabolites | Norcyclobenzaprine |
Elimination half-life | 32 hours (extended-release, range 8–37 hours),[3] 18 hours (immediate release, range 8–37 hours)[4] |
Excretion | Kidney |
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ECHA InfoCard | 100.005.588 |
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Formula | C20H21N |
Molar mass | 275.395 g·mol−1 |
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Common side effects include headache, feeling tired, dizziness, and dry mouth.[5] Serious side effects may include an irregular heartbeat.[5] There is no evidence of harm in pregnancy, but it has not been well studied in this population.[5] It should not be used together with MAOIs.[5] How it works is unclear.[5]
Cyclobenzaprine was approved for medical use in the United States in 1977.[5] It is available by prescription as a generic medication.[5] In 2021, it was the 45th most commonly prescribed medication in the United States, with more than 15 million prescriptions.[6][7] It was not available in the United Kingdom as of 2012.[8]