Christine Guthrie
American geneticist / From Wikipedia, the free encyclopedia
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Christine Guthrie (1945-2022) was an American yeast geneticist and American Cancer Society Research Professor of Genetics at University of California San Francisco.[1] She showed that yeast have small nuclear RNAs (snRNAs) involved in splicing pre-messenger RNA into messenger RNA in eukaryotic cells.[1] Guthrie cloned and sequenced the genes for yeast snRNA and established the role of base pairing between the snRNAs and their target sequences at each step in the removal of an intron.[1] She also identified proteins that formed part of the spliceosome complex with the snRNAs.[1] Elected to the National Academy of Sciences in 1993,[2] Guthrie edited Guide to Yeast Genetics and Molecular Biology, an influential methods series for many years.[3]
Christine Guthrie | |
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Born | (1945-04-27)April 27, 1945 |
Died | July 1, 2022(2022-07-01) (aged 77) |
Education | University of Michigan |
Alma mater | University of Wisconsin |
Known for | Genetics of yeast |
Spouse | John Abelson |
Awards | Genetics Society of America Medal |
Scientific career | |
Fields | Genetics |
Institutions | University of California, San Francisco |
Doctoral advisor | Masayasu Nomura |