Choline acetyltransferase
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Choline acetyltransferase (commonly abbreviated as ChAT, but sometimes CAT) is a transferase enzyme responsible for the synthesis of the neurotransmitter acetylcholine. ChAT catalyzes the transfer of an acetyl group from the coenzyme acetyl-CoA to choline, yielding acetylcholine (ACh). ChAT is found in high concentration in cholinergic neurons, both in the central nervous system (CNS) and peripheral nervous system (PNS). As with most nerve terminal proteins, ChAT is produced in the body of the neuron and is transported to the nerve terminal, where its concentration is highest. Presence of ChAT in a nerve cell classifies this cell as a "cholinergic" neuron. In humans, the choline acetyltransferase enzyme is encoded by the CHAT gene.[5]
Choline acetyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.3.1.6 | ||||||||
CAS no. | 9012-78-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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CHAT | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | CHAT, CHOACTASE, CMS1A, CMS1A2, CMS6, choline O-acetyltransferase | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 118490; MGI: 88392; HomoloGene: 40693; GeneCards: CHAT; OMA:CHAT - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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