Cefuroxime axetil
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Cefuroxime axetil, sold under the brand name Ceftin among others, is a second generation oral cephalosporin antibiotic.
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Zinnat, Ceftin, Ceftum |
Other names | Cefuroxime 1-acetoxyethyl ester |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601206 |
Routes of administration | By mouth, intravenous, intramuscular |
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Pharmacokinetic data | |
Bioavailability | well absorbed |
Metabolism | Cefuroxime is not metabolized and excreted as it is in urine, axetil is metabolized to acetaldehyde and acetic acid[medical citation needed] |
Excretion | Urine |
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ECHA InfoCard | 100.166.374 |
Chemical and physical data | |
Formula | C20H22N4O10S |
Molar mass | 510.47 g·mol−1 |
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It is an acetoxyethyl ester prodrug of cefuroxime which is effective orally.[2] The activity depends on in vivo hydrolysis and release of cefuroxime tablets.[citation needed]
It was patented in 1976 and approved for medical use in 1987.[3]