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Candesartan
Angiotensin II receptor antagonist / From Wikipedia, the free encyclopedia
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Candesartan is an angiotensin receptor blocker used mainly for the treatment of high blood pressure and congestive heart failure. Candesartan has a very low maintenance dose. Like olmesartan, the metabolism of the drug is unusual as it is a cascading prodrug. Candesartan has good bioavailibility and is the most potent by weight of the AT-1 receptor antagonists.
Quick Facts Clinical data, Pronunciation ...
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Pronunciation | /ˌkændɪˈsɑːrtən/ |
Trade names | Atacand, others |
Other names | Candesartan cilexetil |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601033 |
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Routes of administration | By mouth |
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Bioavailability | 15% (candesartan cilexetil) |
Metabolism | Candesartan cilexetil: intestinal wall; candesartan: hepatic (CYP2C9) |
Elimination half-life | 9 hours |
Excretion | Kidney 33%, faecal 67% |
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ECHA InfoCard | 100.132.654 ![]() |
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Formula | C24H20N6O3 |
Molar mass | 440.463 g·mol−1 |
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It was patented in 1990 and approved for medical use in 1997.[2]