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Chemical compound From Wikipedia, the free encyclopedia
Calyculins are natural products originally isolated from the marine sponge Discodermia calyx.[2] Calyculins have proven to be strong serine/threonine protein phosphatase inhibitors and based on this property, calyculins might be potential tumor-promoting agents.
![]() Calyculins A and C | |
Names | |
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IUPAC name
((2R,3R,5R,7R,8S,9S)-2-((1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyltetradeca-7,9,11,13-tetraenyl)-9-((E)-3-(2-((2S)-4-(((2S,3S,4S)-4-(dimethylamino)-2,3-dihydroxy-5-methoxypentanoyl)amino)butan-2-yl)-1,3-oxazol-4-yl)prop-2-enyl)-7-hydroxy-4,4,8-trimethyl-1,10-dioxaspiro(4.5)decan-3-yl) dihydrogen phosphate (Calyculin A)[1] | |
Identifiers | |
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ChEMBL | |
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PubChem CID |
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UNII |
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Properties | |
C51H83N4O15P (Calyculin C) | |
Molar mass | 1023.2 g/mol (Calyculin C) |
Properties | |
C50H81N4O15P (Calyculin A) | |
Molar mass | 1009.17 g/mol (Calyculin A) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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A laboratory synthesis of calyculin A has been reported.[3]
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