COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene.[5][6][7] It encodes a subunit of the COP9 signalosome.
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The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[7]
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