CHRNA10

Neuronal acetylcholine receptor subunit alpha-10, also known as nAChRα10 and cholinergic receptor nicotinic alpha 10, is a protein that in humans is encoded by the CHRNA10 gene.^[5] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

CHRNA10
Identifiers
Aliases	CHRNA10, cholinergic receptor nicotinic alpha 10 subunit
External IDs	OMIM: 606372; MGI: 3609260; HomoloGene: 56886; GeneCards: CHRNA10; OMA:CHRNA10 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 3,665,587 bp[1] End 3,671,384 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 101,760,473 bp[2] End 101,766,035 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh gonad testicle granulocyte mucosa of transverse colon blood right lobe of liver cerebellar hemisphere right hemisphere of cerebellum Top expressed in embryo olfactory bulb muscle of thigh muscle tissue quadriceps femoris muscle skeletal muscle tissue blastocyst spermatocyte lip esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel activity ion channel activity signaling receptor binding extracellular ligand-gated ion channel activity acetylcholine-gated cation-selective channel activity transmembrane signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane perikaryon postsynaptic membrane membrane plasma membrane synapse axon cell junction cholinergic synapse integral component of postsynaptic specialization membrane integral component of plasma membrane neuron projection Biological process positive regulation of cytosolic calcium ion concentration synaptic transmission, cholinergic ion transport detection of mechanical stimulus involved in sensory perception of sound regulation of cell population proliferation calcium ion transmembrane transport inner ear morphogenesis calcium ion transport regulation of postsynaptic membrane potential excitatory postsynaptic potential signal transduction ion transmembrane transport negative regulation of ERK1 and ERK2 cascade chemical synaptic transmission regulation of membrane potential nervous system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57053 504186 Ensembl ENSG00000129749 ENSMUSG00000066279 UniProt Q9GZZ6 n/a RefSeq (mRNA) NM_001303034 NM_001303035 NM_020402 NM_001081424 RefSeq (protein) NP_001289963 NP_001289964 NP_065135 n/a Location (UCSC) Chr 11: 3.67 – 3.67 Mb Chr 7: 101.76 – 101.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.^[6] Furthermore, selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.^[7]

α10 subunit-containing receptors are notably blocked by nicotine. The role of this antagonism in the effects of tobacco are unknown.

References

1. GRCh38: Ensembl release 89: ENSG00000129749 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066279 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA (May 2001). "Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)". Genomics. 73 (3): 272–83. doi:10.1006/geno.2000.6503. PMID 11350119.
6. Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J (December 2007). "The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system". Proc. Natl. Acad. Sci. U.S.A. 104 (51): 20594–9. Bibcode:2007PNAS..10420594V. doi:10.1073/pnas.0708545105. PMC 2154476. PMID 18077337.
7. Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006). "Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–4. Bibcode:2006PNAS..10317880V. doi:10.1073/pnas.0608715103. PMC 1635975. PMID 17101979.

External links

• CHRNA10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CHRNA10 genome location and CHRNA10 gene details page in the UCSC Genome Browser.