CCNI (gene)

Cyclin-I is a protein that in humans is encoded by the CCNI gene.^[4][5]

CCNI
Identifiers
Aliases	CCNI, CCNI1, CYC1, CYI, cyclin I
External IDs	MGI: 1341077; HomoloGene: 4979; GeneCards: CCNI; OMA:CCNI - orthologs
Gene location (Mouse) Chr. Chromosome 5 (mouse)[1] Band 5|5 E2 Start 93,329,792 bp[1] End 93,354,354 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in ganglionic eminence tail of embryo dentate gyrus of hippocampal formation granule cell ventricular zone spermatocyte cerebellar cortex primary visual cortex superior frontal gyrus ovary hippocampus proper BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding Cellular component cyclin-dependent protein kinase holoenzyme complex nucleus cytoplasm Biological process spermatogenesis regulation of cell cycle regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle protein phosphorylation regulation of mitotic nuclear division positive regulation of cell population proliferation positive regulation of cell cycle mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10983 12453 Ensembl ENSG00000118816 ENSMUSG00000063015 UniProt Q14094 Q9Z2V9 RefSeq (mRNA) NM_006835 NM_017367 RefSeq (protein) NP_006826 NP_001335061 NP_001335062 NP_001335063 NP_001335064 NP_001335065 NP_001335066 NP_001335067 NP_001335068 NP_001335069 NP_059063 Location (UCSC) n/a Chr 5: 93.33 – 93.35 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. The function of this cyclin has not yet been determined.^[5]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000063015 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Nakamura T, Sanokawa R, Sasaki YF, Ayusawa D, Oishi M, Mori N (Jan 1996). "Cyclin I: a new cyclin encoded by a gene isolated from human brain". Exp Cell Res. 221 (2): 534–42. doi:10.1006/excr.1995.1406. PMID 7493655.
5. "Entrez Gene: CCNI cyclin I".

External links

• Human CCNI genome location and CCNI gene details page in the UCSC Genome Browser.
• Human CYC1 genome location and CYC1 gene details page in the UCSC Genome Browser.

Further reading

• Sun ZL, Zhu Y, Wang FQ, et al. (2007). "Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers". Biochim. Biophys. Acta. 1774 (6): 764–71. doi:10.1016/j.bbapap.2007.04.001. PMID 17507299.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhu X, Naz RK (1998). "Expression of a novel isoform of cyclin I in human testis". Biochem. Biophys. Res. Commun. 249 (1): 56–60. doi:10.1006/bbrc.1998.9052. PMID 9705831.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.