CABIN1

Calcineurin-binding protein cabin-1 is a protein that in humans is encoded by the CABIN1 gene.^[5][6][7]

CABIN1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1N6J
Identifiers
Aliases	CABIN1, CAIN, PPP3IN, KB-318B8.7, calcineurin binding protein 1
External IDs	OMIM: 604251; MGI: 1298375; HomoloGene: 49307; GeneCards: CABIN1; OMA:CABIN1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.23 Start 24,011,192 bp[1] End 24,178,628 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 38.56 cM Start 75,481,946 bp[2] End 75,600,175 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum paraflocculus of cerebellum granulocyte right uterine tube right lobe of thyroid gland right coronary artery apex of heart left lobe of thyroid gland popliteal artery tibial arteries Top expressed in zygote granulocyte secondary oocyte primary visual cortex ventricular zone superior frontal gyrus neural layer of retina yolk sac tail of embryo lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase inhibitor activity nucleosome binding Cellular component aggresome nucleus nucleoplasm cytosol Biological process cell surface receptor signaling pathway negative regulation of phosphoprotein phosphatase activity chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23523 104248 Ensembl ENSG00000099991 ENSG00000281670 ENSMUSG00000020196 UniProt Q9Y6J0 n/a RefSeq (mRNA) NM_001199281 NM_001201429 NM_012295 NM_172549 RefSeq (protein) NP_001186210 NP_001188358 NP_036427 n/a Location (UCSC) Chr 22: 24.01 – 24.18 Mb Chr 10: 75.48 – 75.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.^[7]

Interactions

CABIN1 has been shown to interact with:

• Amphiphysin,^[8]
• MEF2B,^[9][10]
• MEF2D,^[10][11] and
• SIN3A.^[11]

References

1. ENSG00000281670 GRCh38: Ensembl release 89: ENSG00000099991, ENSG00000281670 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020196 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sun L, Youn HD, Loh C, Stolow M, He W, Liu JO (Jun 1998). "Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes". Immunity. 8 (6): 703–11. doi:10.1016/S1074-7613(00)80575-0. PMID 9655484.
6. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
7. "Entrez Gene: CABIN1 calcineurin binding protein 1".
8. Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH (Nov 2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". The Journal of Biological Chemistry. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.
9. Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L (Apr 2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature. 422 (6933): 730–4. Bibcode:2003Natur.422..730H. doi:10.1038/nature01555. PMID 12700764. S2CID 4430658.
10. Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067.
11. Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10.1016/s1074-7613(00)00010-8. PMID 10933397.

Further reading

• Liu JO (Nov 2003). "Endogenous protein inhibitors of calcineurin". Biochemical and Biophysical Research Communications. 311 (4): 1103–9. doi:10.1016/j.bbrc.2003.10.020. PMID 14623296.
• Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN (May 1997). "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell. 89 (3): 349–56. doi:10.1016/S0092-8674(00)80215-9. PMID 9150134.
• Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Youn HD, Grozinger CM, Liu JO (Jul 2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". The Journal of Biological Chemistry. 275 (29): 22563–7. doi:10.1074/jbc.C000304200. PMID 10825153.
• Lai MM, Luo HR, Burnett PE, Hong JJ, Snyder SH (Nov 2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". The Journal of Biological Chemistry. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.
• Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10.1016/S1074-7613(00)00010-8. PMID 10933397.
• Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J (Nov 2001). "Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells". The Journal of Experimental Medicine. 194 (10): 1449–59. doi:10.1084/jem.194.10.1449. PMC 2193671. PMID 11714752.
• Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L (Apr 2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature. 422 (6933): 730–4. Bibcode:2003Natur.422..730H. doi:10.1038/nature01555. PMID 12700764. S2CID 4430658.
• Tagami H, Ray-Gallet D, Almouzni G, Nakatani Y (Jan 2004). "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis". Cell. 116 (1): 51–61. doi:10.1016/S0092-8674(03)01064-X. PMID 14718166.
• Rodríguez A, Martínez-Martínez S, López-Maderuelo MD, Ortega-Pérez I, Redondo JM (Mar 2005). "The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT". The Journal of Biological Chemistry. 280 (11): 9980–4. doi:10.1074/jbc.C400401200. PMID 15671033.
• Li XN, Li YL, Liu GB, Ding YQ (Jan 2005). "Selection of choriocarcinoma-associated genes using bioinformatics". Di 1 Jun Yi da Xue Xue Bao = Academic Journal of the First Medical College of PLA. 25 (1): 1–6. PMID 15683985.
• Pan F, Means AR, Liu JO (Jun 2005). "Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation". The EMBO Journal. 24 (12): 2104–13. doi:10.1038/sj.emboj.7600685. PMC 1150881. PMID 15902271.
• Jang H, Cho EJ, Youn HD (Jul 2007). "A new calcineurin inhibition domain in Cabin1". Biochemical and Biophysical Research Communications. 359 (1): 129–35. doi:10.1016/j.bbrc.2007.05.066. PMID 17531200.

External links

• Human CABIN1 genome location and CABIN1 gene details page in the UCSC Genome Browser.
• Human KB-318B8.7 genome location and KB-318B8.7 gene details page in the UCSC Genome Browser.