Butorphanol
Opioid analgesic / From Wikipedia, the free encyclopedia
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Butorphanol is a morphinan-type synthetic agonist–antagonist opioid analgesic developed by Bristol-Myers.[2][3][4][5][6] Butorphanol is most closely structurally related to levorphanol. Butorphanol is available as the tartrate salt in injectable, tablet, and intranasal spray formulations. The tablet form is only used in dogs, cats and horses due to low bioavailability in humans.
Quick Facts Clinical data, Trade names ...
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Trade names | Stadol, others |
Other names | BC 2627 |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
MedlinePlus | a682667 |
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Routes of administration | IV, intranasal, oral |
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Bioavailability | Nasal: 60-70%, Sublingual/Buccal 25%-35%. PO < OR= to 10%. * Try to use IN route best used out of the hospital setting or both choices. has longer duration of action ~ 5 hours. IV 2-4 hours. Avoid oral route unless stronger advised by a physician. |
Metabolism | Liver hydroxylated & glucuronidated |
Elimination half-life | 4-7 hours |
Excretion | Kidney, 75% Biliary, 11-14% Fecal, 15% |
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ECHA InfoCard | 100.050.717 |
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Formula | C21H29NO2 |
Molar mass | 327.468 g·mol−1 |
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It was patented in 1971 and approved for medical use in 1979.[7]