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Brotizolam
Benzodiazepine / From Wikipedia, the free encyclopedia
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Brotizolam[3] (marketed under brand name Lendormin) is a sedative-hypnotic[4] thienotriazolodiazepine[5] drug which is a benzodiazepine analog.[6] It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties, and is considered to be similar in effect to other short-acting hypnotic benzodiazepines such as triazolam or midazolam.[7] It is used in the short-term treatment of severe insomnia. Brotizolam is a highly potent and short-acting hypnotic, with a typical dose ranging from 0.125 to 0.25 milligrams, which is rapidly eliminated with an average half-life of 4.4 hours (range 3.6–7.9 hours).[8]
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Trade names | Lendormin |
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Routes of administration | Oral |
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Bioavailability | 48–95% |
Metabolism | Hepatic |
Elimination half-life | 4.4 hours (range, 2.6–6.9 h) |
Excretion | Renal |
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ECHA InfoCard | 100.055.404 ![]() |
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Formula | C15H10BrClN4S |
Molar mass | 393.69 g·mol−1 |
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It was patented in 1974[9] and came into medical use in 1984.[10] Brotizolam is not approved for sale in the UK, United States or Canada. It is approved for sale in the Netherlands, Germany, Spain, Belgium, Luxembourg, Austria, Portugal, Israel, Italy, Taiwan and Japan.