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Chemical compound From Wikipedia, the free encyclopedia
Broparestrol (INN ) (brand names Acnestrol, Longestrol; former developmental code name LN-107), also known as α-bromo-α,β-diphenyl-β-p-ethylphenylethylene (BDPE), is a synthetic, nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group[1] that has been used in Europe as a dermatological agent and for the treatment of breast cancer.[2][3][4][5][6] The drug is described as slightly estrogenic[7] and potently antiestrogenic,[8][9] and inhibits mammary gland development and suppresses prolactin levels in animals.[10] It is structurally related to clomifene and diethylstilbestrol.[6][10] Broparestrol is a mixture of E- and Z- isomers (LN-1643 and LN-2299, respectively), both of which are active, and are similarly antiestrogenic but, unlike broparestrol, were never marketed.[2]
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Trade names | Acnestrol, Longestrol |
Other names | LN-107; α-Bromo-α,β-diphenyl-β-p-ethylphenylethylene; BDPE |
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Routes of administration | By mouth |
Drug class | Selective estrogen receptor modulator |
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Formula | C22H19Br |
Molar mass | 363.298 g·mol−1 |
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