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Antimicrobial peptide-like immune gene of fruit flies From Wikipedia, the free encyclopedia
The Bomanin gene family encodes a group of immune peptides that are essential for Drosophila fruit fly defence against infection by many pathogens.[1][2]
Bomanin | |||||||
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Identifiers | |||||||
Organism | |||||||
Symbol | Bom | ||||||
UniProt | P82706 | ||||||
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The gene family is named in honour of Hans G. Boman, for his contributions to innate immunity and the discovery of antimicrobial peptides.[1] While Bomanins are essential for survival after infection by many kinds of Gram-positive bacteria and pathogenic fungi, the reason they are key to defence may be because Bomanins promote resilience to pathogen toxins, and not because they directly suppress pathogens.[3] However fly hemolymph (blood) loses its fungicidal activity in the absence of Bomanins, suggesting these peptides are also somehow needed to turn the hemolymph into an antimicrobial environment.[4]
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