Bioprinting drug delivery
Bioprinting drug delivery systems / From Wikipedia, the free encyclopedia
Bioprinting drug delivery is a method for producing drug delivery vehicles. It uses three-dimensional printing of biomaterials via additive manufacturing. Such vehicles are biocompatible, tissue-specific hydrogels or implantable devices. 3D bioprinting prints cells and biological molecules to form tissues, organs, or biological materials in a scaffold-free manner that mimics living human tissue. The technique allows targeted disease treatments with scalable and complex geometry.
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This technique was first developed in the 1950s as patients with incurable diseases sought organ transplantations beyond those available from donors. Organ transplantation showed limitations with immune responses and organ rejection.[1]
Techniques that have been studied include bioprinting hydrogels with various Bio-ink (cell-laden microgel) materials and bioprinting implantable devices that mimic specific tissues or biological functions. Applications include promoting wound healing by delivering antibiotics, anti-inflammatory treatments, or drugs that promote cell differentiation and cell proliferation, providing anticancer treatments directly to tumors, and promoting/inhibiting angiogenesis and vascularization to treat cancer, arterial diseases, heart diseases, and arthritis. In addition, implants can be printed in unique shapes and forms to deliver drugs directly to targeted tissues. One approach adds a fourth dimension, which allows the materials to conform, by folding/unfolding, to release drugs in a more controlled manner. Bioprinting allows for biocompatible, biodegradable, universal, and personalized delivery vehicles.